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How to defeat Bio-Bulkhead in Borderlands 4

September 16, 2025 8 Min Read
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8 Min Read
How to defeat Bio-Bulkhead in Borderlands 4
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Table of Contents

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  • Bio-Bulkhead location in Borderlands 4
  • Bio-Bulkhead’s moveset
  • Bio-Bulkhead rewards

Borderlands 4’s Bio-Bulkhead is among the first bosses you battle within the recreation and the grappling hook is prime to get to the boss. Not like something you have got confronted up to now within the recreation, Bio-Bulkhead gained’t be crushed by merely capturing every part you have got at them.

In our Borderlands 4 information, we clarify methods to defeat Bio-Bulkhead, together with the rewards you obtain from this battle.


Bio-Bulkhead location in Borderlands 4

You have to defeat Bio-Bulkhead to progress within the marketing campaign because it’s the ultimate boss within the “One Fell Swoop” quest. The search doesn’t finish proper after the battle, however you don’t produce other bosses till the final second of this mission.

A Borderlands 4 screenshot showing on the map where players find the Bio-Bulkhead boss Picture: Gearbox Software program/2K Video games by way of gamexplore

To seek out Bio-Bulkhead, you might want to invade Sol’s manufacturing facility in Artificial Nave, which is situated within the Dissected Plateau space (verify our Borderlands 4 interactive map to seek out it). As soon as inside, assist Zadra enter the lab. You will see that a door that’s protected by an impenetrable protect. To interrupt it, you should use the air duct northwest of the room to entry the lab.

A Borderlands 4 screenshot showing where players find the locust capsule to open the gate during the "One Fell Swoop" quest Picture: Gearbox Software program/2K Video games by way of gamexplore

Kill the enemies and activate the lever to get a pattern of Locust. Now, you might want to use your grappling hook to seize a capsule and throw it on the gate. Repeat the identical course of within the room the place Zadra is.

Transfer ahead to seek out a few merchandising machines earlier than the boss area.


Bio-Bulkhead’s moveset

Along with Bio-Bulkhead, there will probably be a number of androids who spawn sporadically round as properly. Though these androids might be fairly annoying, it’s best to attempt to at all times preserve one alive in case you might be down in “Struggle for Your Life” mode and must kill an enemy to get again in your ft.

A montage of two Borderlands 4 images showing the Bio-Bulkhead's health bar and how they can identify if the boss has its shield up Graphic: Paulo Kawanishi/gamexplore | Supply photos: Gearbox Software program/2K Video games by way of gamexplore

The principle mechanic it’s best to take note of entails Bio-Bulkhead’s protect. You may establish if the protect is up by checking Bio-Bulkhead’s well being bar. Every time it has traces crossing over the well being bar, it means the boss gained’t take any harm.

A montage of two Borderlands 4 images showing where players can find the locust capsules during the fight against Bio-Bulkhead Graphic: Paulo Kawanishi/gamexplore | Supply photos: Gearbox Software program/2K Video games by way of gamexplore

To briefly destroy Bio-Bulkhead’s protect, you might want to throw a Locust capsule at it. You could find some within the northern a part of the decrease stage and the southern a part of the higher stage. There are not any visible or audio cues indicating when the protect is coming again, however in our expertise, the boss bought it again up 3 times all through the battle.

All through the battle, Bio-Bulkhead will preserve chasing you, so you may really simply steer clear of it and shoot whereas strolling backward. You need to use the steps and pillars within the area to create house between you and the boss whereas discovering cowl from the android’s photographs as properly.

A Borderlands 4 screenshot showing the Bio-Bulkhead boss Picture: Gearbox Software program/2K Video games by way of gamexplore

Bio-Bulkhead can rapidly attain you, so be able to sprint out of its assaults and preserve a protected distance. The boss’s weak spot is its head, so intention for it to maximise your harm.

Beneath, you discover a extra detailed clarification of its moveset:

  • Soar assault: Bio-Bulkhead jumps in place and creates a shock wave round it. The world the place it lands turns into stuffed with electrical energy, which you will additionally need to keep away from. If you’re far sufficient from the boss, this assault isn’t an issue. Nonetheless, if Bio-Bulkhead makes use of its bounce assault after a gap-closer, then it’s best to use your backpack to glide and sprint out of it.
  • Frontal shock wave: When hitting the bottom with each fingers, Bio-Bulkhead creates frontal shock waves. Since these waves journey an extended distance from the place the boss is, attempting to run from them isn’t very efficient. Do your finest to glide and sprint to the edges.
  • Blue projectile: The boss slams its fists to create a blue projectile that flies ahead following an S-shaped sample. It’s tough to keep away from this one. sp attempt to time your sprint for when it’s getting shut. There are two variations of this assault, one with a single projectile and one other with two.
  • Hole nearer: If you’re removed from the boss, it might bounce to the place you might be. When you can keep away from this assault by working, the perfect technique is to really sprint towards the route it’s coming from.

Bio-Bulkhead rewards

Defeating Bio-Bulkhead rewards you with expertise factors and weapons, and like different boss fights, you may repeat it by paying a certain quantity to Moxxi’s machine. After we fought it for the primary time, at stage 15, we earned 486 XP. At stage 35 within the Final Vault Hunter mode Rank 1, we bought 2,080 expertise factors.

A Borderlands 4 screenshot showing guns jumping from the Bio-Bulkhead's body after it was defetead Picture: Gearbox Software program/2K Video games by way of gamexplore

Whereas the drops are random, we all know that you could be get the next legendary drops: Sho Kunai, Waterfall grenades, and Funds Deity pistol. After the battle, there’s additionally a purple chest to open. What you get from it modifications each time, however there’s a excessive probability of getting good loot from one of these chest.


Do you want extra assist with Borderlands 4? For many who are new to Kairos, take a look at our newbie’s information earlier than you get began and our greatest courses information to seek out the precise one in your playstyle.

If you wish to have enjoyable along with your weapons, make sure you learn our information on methods to get extra SDU tokens. We all know that traversing the immense map of Kairos is a problem in itself, so it’s best to prioritize unlocking a car, in addition to quick journey factors. And in case you’re already having fun with the endgame of Borderlands 4, don’t neglect to verify the weekly reset time for all present challenges.

See also  S.T.A.L.K.E.R. 2: Heart of Chornobyl Q2 Roadmap Includes Mutant Loot, New Weapons, and A-Life 2.0 Updates

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